Well with nitrous if you play safe then no problems. If you start to tinker with the jets looking for more power beyond what the company says will work and is safe then you are playing with fire. It's true with most things, and especially true with nitrous, you get what you pay for. The more you spend on accessories (bottle heater, gauges, fuel pressure safety switch) the safe you are and the better your system will work.
The octane boosters work, and if you want to spray big (say more than 100-125) then use them, or UNLEADED race gas mixed with 93 octane. NEVER spray a hemi truck running anything less than 93 octane. These motors run on the edge of detonation already and nitrous can make that worse if you run cheap gas. ALWAYS run your superchips on "stock" or 87 tune. (The 87 tune actually retards timing which is a good thing on spray).
You should always run the NGK 4306 plugs. Don't run the iridiums, the bosch +2+3+4+10's or splitfires or ANY other plug. Gap the plugs to .035 or .040
Always run a wideband A/F guage too. Try and keep you A/F no higher than 13.0 and 12.5-12.0 is good on the nitrous. Too lean and you have problems.
Nitrous is great stuff, buy a good quality kit from a good company and follow the directions. Don't listen when the internet guys tell you to "change your jets to XX and XX" without calling the company who made your kit to see if it's ok on their system. Different companies use different jets and they are NOT the same.
The only drawback is when you have a problem, the damage will usually be done before you can see. hear or feel it, and it's usually expensive to fix.