From a towing standpoint, the CTD likes to pull in the well published "sweet spot" of 2,200 RPM. Mind you, this is for sustained, heavy towing. Heavy towing is anything around the max weight listed for the truck or above.
With my 3.73's, I need a speed of about 75 mph to be in the sweet spot. Out west with speed limits of 75 mph and long stretches of interstate, the 3.73s really shine. On the east coast, with 65 mph speed limits, 4.10 would keep the rig in the spot better.
Long grades and heavy loads are another factor. With the EZ and pulling 15,000 lbs, I need to downshift into 5th and drive by EGTs on the big hills. Keeping the RPMs up in the power range can be best appreciated pulling heavy.