Yes, as long as the foundation is good (long block) you can do almost anything to them. There's a guy on here who ran his nitrous'd 5.7 in his 12sec 05 Ram til about 256,000 miles til he had to rebuild it (excuse to stroke it out to a 392). My 03 has 150,000 and continues to be modded as well as my 06 Charger R/T with 170,000.
03 Hemi Ram, 05 Magnum R/T, 06 Charger R/T
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